Principal Investigators
Joe Warren, Computer Science, Rice University
Yin Zhang, Computational and Applied Mathematics, Rice University


TMC Collaborator
Thomas Guerrero, M.D. Anderson Cancer Center


Summary

We propose to develop information technology for processing time-varying
CT scans (4D CT) of the lungs. In particular, we propose to develop
tools for estimating the ventilation (air flow) and perfusion (blood
flow) from 4D CT and apply these tools to quantitatively assess the
effectiveness of current treatments for lung cancer.


This work made possible in part through support from a Seed Grant from

the Gulf Coast Center for Computational Cancer Research funded by John &

Ann Doerr Fund for Computational Biomedicine.


Initial Proposal - March 2006



Progress Report - October 2006



Progress Report - April 2007



Publications

 
Guerrero, T., K. Sanders, E. Castillo, Y. Zhang, L. Bidaut, T. Pan and R. Komaki (2006). "Dynamic ventilation
 imaging from four-dimensional computed tomography." Physics in Medicine & Biology 51(4): 777-91.
 
Guerrero, T., G. Zhang, T. C. Huang, Z. Liao and K. P. Lin (2004). Intra-thoracic tumor motion estimation from
 CT imaging using 3D optical flow method. Proceedings of the IASTED International Conference on
 Biomedical Engineering, Innsbruck.
 

Guerrero, T. M., R. Castillo, K. Sanders, R. Price, R. Komaki and D. D. Cody (2006). "Novel method to
 calculate pulmonary compliance images in rodents from computed tomography acquired at constant
 pressures." Phys. Med. Biol. 51(5): 1101-1112.
 
Guerrero, T. M., K. Sanders, E. Castillo, Y. Zhang, L. Bidaut, T. Pan and R. Komaki (2006). "Dynamic
 ventilation imaging from four-dimensional computed tomography." Phys. Med. Biol. 51(4): 777–791.
 
Guerrero, T. M., K. Sanders, J. Noyola-Martinez, E. Castillo, Y. Zhang, R. Tapia, R. Guerra, Y. Borghero and
 R. Komaki (2005). "Quantification of regional ventilation from treatment planning CT." Int. J. Radiat.
 Oncol. Biol. Phys. 62(3): 630 - 634.
 
Schaefer S., McPhail T. and Warren J (2006). "Image Deformation Using Moving Least Squares." 
 Proceeds of ACM SIGGRAPH 2006, ACM Press.
 
T. Ju, I. Kakadiaris, M. Bello., J. Warren, G. Eichele, C. Thaller, W. Chiu, and J. Carson,
 Building 3d surface networks from 2d curve networks with application to anatomical
 modeling," in Paci¯c Graphics, 2005.
 
T. Ju, J. Warren, G. Eichele, C. Thaller, W. Chiu, and J. Carson, A geometry database for
 gene expression data," in Eurographics Symposium on Geometry Processing, pp. 166 { 176,
 2003.